Estradiol is a form of Estrogen, a natural hormone that helps regulate the female reproductive system.  It is often prescribed to women experiencing menopause.  Estradiol is used to treat hot flashes, vaginal and vulvar changes such as irritation and dryness, and osteoporosis. 

Adverse Effects of Estradiol
Estradiol has been linked to several severe side effects such as heart disease and breast cancer.  Endometrial hyperplasia, which can lead to cancer in the uterine lining, has recently been linked to Estradiol use.
 
Current Status of Estradiol
Estradiol is an effective way to deal with symptoms of menopause.  Currently, many physicians proscribe taking progesterone along with the Estradiol to reduce some of the severe side effects. 

If you have developed unexplained cancers or other diseases and are currently taking Estradiol, you should consider consulting an experienced products liability attorney to discuss your options and remedies.